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To minimize gastrointestinal side effects, clinicians typically employ gradual dose titration, starting at 2.5 mg weekly and increasing by 2.5 mg increments every 4 weeks based on individual tolerance

13 As a result, initiation of therapy may be more beneficial for patients who require greater glycemic control throughout the day than during the night

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To experimentally test if TyrAs from clade I have ADH activity, representative TyrA orthologs from two distinct subclades of clade I, spirochaetes (SsTyrA) and -proteobacteria ( O